N'oge ọrịa a, ndị dọkịta na-eji ọgwụ mgbochi monoclonal mmịnye ọbara (ọgwụ mgbochi ụlọ nyocha) iji nyere ndị ọrịa aka ịlụso ọrịa COVID-19 ọgụ. Ugbu a ndị nchọpụta UC Davis na-agbalị ịmepụta ọgwụ mgbochi monoclonal nke nwere ike inyere aka ịlụ ọgụ mgbu na-adịghị ala ala. Ebumnuche bụ ịmepụta ihe mgbu na-adịghị riri ahụ kwa ọnwa nke nwere ike dochie opioids.
Ọrụ a bụ Vladimir Yarov-Yarovoi na James Trimmer, ndị ọkachamara na Ngalaba Physiology na Biology of Membrane na Mahadum California, Ụlọ Akwụkwọ Ọgwụ Davis. Ha kpọkọtara otu ìgwè nke ọtụtụ ndị na-eme nchọpụta bụ ndị na-agbalị ime ka venom tarantula ghọọ ihe mgbu.
N'afọ gara aga, Yarov-Yarovoy na Trimmer nwetara $ 1.5 nde onyinye sitere na mmemme HEAL nke National Institutes of Health, nke bụ mgbalị siri ike iji mee ka ngwọta sayensị dịkwuo elu iji nwee nsogbu nke opioid obodo.
N'ihi mgbu na-adịghị ala ala, ndị mmadụ nwere ike ịmalite ịṅụ ọgwụ opioids. Centlọ Ọrụ Maka Nchịkwa Ọrịa nke National Center for Health Statistics na-eme atụmatụ na a ga-enwe ọnwụ 107,622 ịdoụbiga mmanya ókè na United States na 2021, ihe fọrọ nke nta ka ọ bụrụ 15% karịa ọnwụ e mere atụmatụ na 93,655 nwụrụ na 2020.
"Ọganihu ndị na-adịbeghị anya na nhazi usoro na mgbakọ na mwepụ - iji kọmputa na-aghọta na ịmepụta usoro ihe ndị dị ndụ - tọrọ ntọala maka ntinye nke usoro ọhụrụ maka ịmepụta ọgwụ nje dị ka ndị ọkachamara na-ahụ maka ọgwụ ọjọọ maka ịgwọ ọrịa mgbu na-adịghị ala ala," Yarov kwuru. Yarovoy, onye na-eme ihe nkiri Sai award.
Trimmer kwuru, "Mgbochi mgbochi monoclonal bụ mpaghara kachasị na-eto ngwa ngwa nke ụlọ ọrụ ọgwụ ma na-enye ọtụtụ uru karịa ọgwụ obere ụmụ irighiri ihe." Obere ọgwụ molekul bụ ọgwụ ndị na-abanye n'ime sel ngwa ngwa. A na-ejikarị ha eme ihe na nkà mmụta ọgwụ.
N'ime afọ ndị gafeworonụ, ụlọ nyocha Trimmer emepụtala ọtụtụ puku ọgwụ mgbochi monoclonal dị iche iche maka ebumnuche dị iche iche, mana nke a bụ mbọ mbụ imepụta ọgwụ mgbochi emere iji belata mgbu.
Ọ bụ ezie na ọ dị ka ọdịnihu, US Food and Drug Administration akwadola ọgwụ mgbochi monoclonal maka ọgwụgwọ na mgbochi migraine. Ọgwụ ọhụrụ na-arụ ọrụ na protein metụtara migraine nke a na-akpọ peptide metụtara mkpụrụ ndụ calcitonin.
Ọrụ UC Davis nwere ebumnuche dị iche - ọwa ion kpọmkwem na mkpụrụ ndụ akwara akpọrọ voltaji-gated sodium channels. Ọwa ndị a dị ka "pores" na mkpụrụ ndụ akwara.
"Mkpụrụ ndụ akwara na-ahụ maka ịnyefe mgbaàmà mgbu n'ime ahụ. Ọwa sodium ion nke nwere ike ịgbachite anya n'ime mkpụrụ ndụ akwara bụ isi ihe na-ebute mgbu,” ka Yarov-Yarovoy na-akọwa. "Ebumnuche anyị bụ ịmepụta ọgwụ mgbochi na-ejikọta na saịtị mgbasa ozi ndị a kpọmkwem na ọkwa molecular, gbochie ọrụ ha ma gbochie nnyefe nke mgbaàmà mgbu."
Ndị nchọpụta ahụ lekwasịrị anya na ụzọ atọ sodium kpọmkwem metụtara mgbu: NaV1.7, NaV1.8, na NaV1.9.
Ebumnuche ha bụ imepụta ọgwụ mgbochi na-adakọ na ọwa ndị a, dị ka igodo na-emepe mkpọchi. Ezubere ụzọ a ezubere iche iji gbochie nnyefe nke mgbaàmà mgbu site na ọwa na-etinyeghị aka na mgbaàmà ndị ọzọ na-ebufe site na mkpụrụ ndụ akwara.
Nsogbu bụ na nhazi nke ọwa atọ ha na-agbalị igbochi dị mgbagwoju anya.
Iji dozie nsogbu a, ha na-atụgharị na mmemme Rosetta na AlphaFold. Na Rosetta, ndị nchọpụta na-azụlite ụdị protein mebere dị mgbagwoju anya ma na-enyocha ụdị nke kacha mma maka ọwa akwara NaV1.7, NaV1.8 na NaV1.9. Site na AlphaFold, ndị nyocha nwere ike nwalee protein nke Rosetta mepụtara n'onwe ya.
Ozugbo ha chọpụtara protein ole na ole na-ekwe nkwa, ha mepụtara ọgwụ mgbochi ọrịa nke enwere ike ịnwale na anụ ahụ akwara nke emepụtara na ụlọ nyocha. Ọnwụnwa mmadụ ga-ewe ọtụtụ afọ.
Mana ndị nchọpụta nwere obi ụtọ maka ikike nke ụzọ ọhụrụ a nwere. A ghaghị ịṅụ ọgwụ ndị na-abụghị steroidal anti-inflammatory (NSAIDs), dị ka ibuprofen na acetaminophen, ọtụtụ ugboro n'ụbọchị iji belata mgbu. A na-ejikarị ọgwụ mgbu opioid eme ihe kwa ụbọchị ma na-ebu ihe egwu riri ahụ.
Otú ọ dị, ọgwụ mgbochi monoclonal nwere ike ịgbasa n'ọbara ruo ihe karịrị otu ọnwa tupu ahụ agbajisịa ha. Ndị nchọpụta ahụ tụrụ anya ka ndị ọrịa na-enye onwe ha ọgwụ mgbochi analgesic monoclonal otu ugboro n'ọnwa.
"Maka ndị ọrịa nwere mgbu na-adịghị ala ala, nke a bụ kpọmkwem ihe ị chọrọ," ka Yarov-Yarovoy kwuru. "Ha na-enwe ihe mgbu ọ bụghị maka ụbọchị, kama maka izu na ọnwa. A na-atụ anya na ọgwụ mgbochi na-ekesa ga-enwe ike inye ahụ mgbu nke na-adịru ọtụtụ izu. "
Ndị otu ndị ọzọ gụnyere EPFL's Bruno Correia, Yale's Steven Waxman, EicOsis 'William Schmidt na Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, na Robert Stewart nke UC Davis.
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Oge nzipu: Sep-29-2022